Bipolar disorder — sometimes called manic-depressive disorder — is associated with emotional swings that range from the downs of depression to the highs of mania. When your depressive low sets in you may feel hopeless. unhappy, loosing interest or pleasure in most activities. When your mood shifts in the other direction, you may feel euphoric and full of energy. Mood shifts may occur only a few times a year, or radically as often as several times a day. There is quite a range in the experienced symptoms of this disorder. In some cases, bipolar disorder causes a bizarre twist of symptoms where you feel depression and manic at the same time.